Dementia diagnosis can be tricky, but blood tests could help predict it years earlier

Proteins found in the plasma are biological markers for the changes that occur in dementia sufferers over a decade before clinical symptoms appear.

Feb 25, 2024 - 21:00
Dementia diagnosis can be tricky, but blood tests could help predict it years earlier

In the largest study of its kind, scientists have discovered that a blood test detecting specific proteins could predict dementia up to 15 years before a person receives an official diagnosis.

The researchers found 11 proteins that have a remarkable 90% accuracy in predicting future dementia.

Dementia is the UK’s biggest killer. Over 900,000 people in the UK are living with the memory-robbing condition, yet less than two-thirds of people receive a formal diagnosis. Diagnosing dementia is tricky and relies on various methods.

These include lumbar punctures (to look for certain telltale proteins in the cerebrospinal fluid), PET scans and memory tests. These methods are invasive, time-consuming and expensive, putting a heavy burden on the the National Health Service.

This means that many people are only diagnosed when they have memory and cognitive problems. By this point, the dementia may have been progressing for years and any support or health plan may be too late.

Those with undiagnosed dementia, and their families, cannot attend clinical trials, have an organised healthcare plan or access essential support. So improving dementia diagnosis would provide earlier support and give patients a longer, healthier and more prosperous life.

In this latest study, researchers at the University of Warwick in England and Fudan University in China examined blood samples from 52,645...

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